Coming Soon.

Dr. Denis Jacob Machado is an assistant professor in bioinformatics at the University of North Carolina at Charlotte (UNC Charlotte), College of Computing and Informatics (CCI), Department of Bioinformatics and Genomics (BiG), starting on Aug. 15, 2022. He was one of the first hires of the Computational Intelligence to Predict Health and Environmental Risks (CIPHER) research center.

Daniel Janies shall mentor Denis Jacob Machado. Together we shall continue to work with others in Core B (Discovery Core) and Core D (Medicinal Chemistry Core). We shall provide algorithm development and data analyses that are relevant to this extramural group.

James C. Sacchettini is a molecular biologist and protein crystallographer at Texas A&M University. He serves as Director of the Texas A&M Center for Structural biology. He also serves as the director of the NIH Program Project – TB Structural Genomics Consortium (TBSGC), that focuses on structure-guided drug discovery of Mycobacterium tuberculosis (Mtb). His lab is also part of the Bill and Melinda Gates Foundation funded TB Drug Accelerator (TBDA).

Professor Sacchettini’s research has primarily focused on structure-guided drug design and synthesis of novel inhibitors for several different infectious diseases, cancer and neurodegenerative diseases. His lab has developed considerable know-how in fragment, virtual, small molecule and natural product screening to augment expertise in structural guided drug discovery with TB and COVID projects in lead development.