Led by Dr. Tim Willson at the University of North Carolina at Chapel Hill, Core D (Medicinal Chemistry) provides chemistry support to develop direct-acting antiviral (DAA) leads with robust antiviral activity that can ideally be administered in a once daily oral pill. The Core works closely with Core B (Discovery) to identify promising starting points for chemistry campaigns and with Core C (Enzymology) to characterize the mechanism of action of compounds.
Core D fully embraces the Structural Genomics Consortium (SGC) open science principles, which have seeded many successful drug discovery efforts through the creation of >50 chemical probes. The Core includes two SGC sites, one at UNC led by Dr. Tim Willson and the other at University of College London led by Dr. Mat Todd. Read more about our Center’s open science work here.
Team
