Flavivirus

Project 4 is a public-private partnership led by Dr. Olivia Goethals at Janssen Pharmaceuticals with academic researchers at UNC, OHSU, and SLU. This team is focused on finding novel inhibitors of the flavivirus family, which includes multiple viruses that are a significant threat to human health, such as Dengue, West Nile, Yellow Fever, and Zika viruses. There is a critical need for new flavivirus drug development, as there are no direct-acting antivirals approved to treat or prevent these infections.

Project 4 is focused on three targets: the NS5 RNA-dependent-RNA-polymerase (RdRp), the NS3 helicase, and the NS2B-NS3 protease. To learn more about these enzyme classes, visit our Research Overview.

Team

Olivia Goethals

Olivia Goethals

Project Lead

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Marnix Van Loock

Marnix Van Loock

Project Investigator

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Alec Hirsch

Alec Hirsch

Project Investigator

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Long Ping Victor Tse

Long Ping Victor Tse

Project Investigator

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Ralph S. Baric

Ralph S. Baric

Project Investigator

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