We are committed to Open Science, with our early stage hit discovery and hit-to-lead chemistry campaigns led by the Structural Genomics Consortium. As part of this effort, our current chemistry campaigns can be viewed at this link. This work is led by Dr. Tim Willson at the University of North Carolina at Chapel Hill and Dr. Mat Todd at the University of College London.
Additionally, the following documents are summaries of compounds identified in our screening efforts, with the current status of their medicinal chemistry campaigns.
| Compound ID | Target | Status |
|---|---|---|
| Coronavirus | ||
| RA-0001211 Summary | SARS-CoV-2 RdRp | Terminated |
| RA-0001213 Summary | SARS-CoV-2 RdRp | Terminated |
| RA-0001212 Summary | SARS-CoV-2 RdRp | Terminated |
| RA-0002111 Summary | SARS-CoV-2 RdRp | Terminated |
| RA-0010958 Summary | SARS-CoV-2 RdRp | Terminated |
| RA-0010660 Summary | SARS-CoV-2 RdRp | Terminated |
| RA-0010460 Summary | SARS-CoV-2 RdRp | Terminated |
| RA-0002723 Summary | SARS-CoV-2 RdRp | Active Hit Triage |
| RA-0002699 Summary | SARS-CoV-2 RdRp | Terminated |
| RA-0010874 Summary | SARS-CoV-2 nsp15 | Active Hit Triage |
| RA-0002243 Summary | SARS-CoV-2 nsp13 | Terminated |
| RA-0001250 Summary | SARS-CoV-2 nsp13 | Terminated |
| RA-0001313 Summary | SARS-CoV-2 nsp13 | Terminated |
| RA-0001264 Summary | SARS-CoV-2 nsp13 | Terminated |
| RA-0020084 Summary | SARS-CoV-2 nsp10/14 | Active Hit Triage |
| RA-0020081 Summary | SARS-CoV-2 nsp10/14 | Active Hit Triage |
| Filovirus | ||
| RA-0010200 Summary | EBOV RdRp | Active Hit Triage |
| Flavivirus | ||
| RA-0003301 Summary | DENV2 RdRp | Active Hit Triage |
| RA-0003150 Summary | DENV2 RdRp | Active Hit Triage |
| RA-0002956 Summary | DENV2 RdRp | Active Hit Triage |
| RA-0002927 Summary | DENV2 RdRp | Active Hit Triage |
| RA-0002923 Summary | DENV2 RdRp | Active Hit Triage |
| RA-0002920 Summary | DENV2 RdRp | Active Hit Triage |
| RA-0002911 Summary | DENV2 RdRp | Active Hit Triage |
| RA-0001930 Summary | DENV2 RdRp | Terminated |
| Alphavirus | ||
| RA-0020364 Summary | CHIKV nsP2-Protease | Active Hit-to-Lead |
| RA-0020336 Summary | CHIKV nsP2-Protease | Active Hit Triage |
| RA-0002888 Summary | CHIKV nsP2-Protease | Active Hit Triage |
| RA-0002885 Summary | CHIKV nsP2-Protease | Active Hit Triage |
| RA-0002873 Summary | CHIKV nsP2-Protease | Active Hit Triage |
| RA-0002125 Summary | CHIKV nsP2-Protease | Terminated |
| RA-0002121 Summary | CHIKV nsP2-Protease | Active Hit-to-Lead |
| RA-0002034 Summary | CHIKV nsP2-Protease | Active Lead Optimization |
| RA-0001821 Summary | CHIKV nsP2-Helicase | Active Hit-to-Lead |
| RA-0001819 Summary | CHIKV nsP2-Helicase | Terminated |
| RA-0020031 Summary | CHIKV nsP2-Helicase | Active Hit Triage |
| RA-0003656 Summary | CHIKV nsP2-Helicase | Active Hit Triage |